Edward C. Cooper

Neurology

6550 Fannin St Ste 1801
Houston, TX 77030

Last Updated: 09/26/2026

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Found 30 publications

Molecular dynamics of the pathogenic KCNQ2 variant G256W reveals mechanisms of channel dysfunction in epileptic encephalopathy.

Molecular dynamics of the pathogenic KCNQ2 variant G256W reveals mechanisms of channel dysfunction in epileptic encephalopathy.

Journal: Journal of biomolecular structure & dynamics

Published: February 11, 2026

Molecular dynamics of the pathogenic KCNQ2 variant G256W reveal mechanisms of channel dysfunction in epileptic encephalopathy.

Molecular dynamics of the pathogenic KCNQ2 variant G256W reveal mechanisms of channel dysfunction in epileptic encephalopathy.

Journal: bioRxiv : the preprint server for biology

Published: December 18, 2025

Early sodium channel blocker initiation is associated with better outcomes in KCNQ2 disorders.

Early sodium channel blocker initiation is associated with better outcomes in KCNQ2 disorders.

Journal: Brain : a journal of neurology

Published: October 17, 2025

Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy.

Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy.

Journal: eLife

Published: January 06, 2025

Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy.

Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy.

Journal: bioRxiv : the preprint server for biology

Published: January 23, 2024

Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment.

Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Published: October 10, 2023

KCNA1 gain-of-function epileptic encephalopathy treated with 4-aminopyridine.

KCNA1 gain-of-function epileptic encephalopathy treated with 4-aminopyridine.

Journal: Annals of clinical and translational neurology

Published: November 17, 2022

Genetic Variant in Nicotinic Receptor α4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening.

Genetic Variant in Nicotinic Receptor α4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening.

Journal: International journal of molecular sciences

Published: September 21, 2022

High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity.

High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity.

Journal: JCI insight

Published: February 01, 2022

KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism.

KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism.

Journal: EBioMedicine

Published: January 22, 2022

KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist.

KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist.

Journal: Neuron

Published: January 20, 2022

Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine.

Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine.

Journal: Experimental neurology

Published: December 31, 2021

Showing 1-12 of 30

Last Updated: 09/26/2026