Last Updated: 09/26/2026
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Found 11 publications
The discovery and preclinical pharmacology of JNJ-10450232 (NTM-006), a centrally penetrant, non-opioid structural analog of acetaminophen with comparable analgesic and anti-pyretic properties but no evidence of hepatotoxicity.
Journal: Regulatory toxicology and pharmacology : RTP
Published: September 15, 2024
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Journal: Regulatory toxicology and pharmacology : RTP
Published: August 01, 2022
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.
Journal: Regulatory toxicology and pharmacology : RTP
Published: July 05, 2022
JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction.
Journal: Regulatory toxicology and pharmacology : RTP
Published: July 05, 2022
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen.
Journal: Regulatory toxicology and pharmacology : RTP
Published: November 29, 2021
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential.
Journal: Regulatory toxicology and pharmacology : RTP
Published: July 15, 2020
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
Journal: Regulatory toxicology and pharmacology : RTP
Published: July 14, 2020
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential.
Journal: Regulatory toxicology and pharmacology : RTP
Published: June 03, 2020
Comparison of the Efficacy and Safety of 2 Acetaminophen Dosing Regimens in Febrile Infants and Children: A Report on 3 Legacy Studies.
Journal: The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Published: March 25, 2017
New insights into root causes of pediatric accidental unsupervised ingestions of over-the-counter medications.
Journal: Clinical toxicology (Philadelphia, Pa.)
Published: November 29, 2013
Dosing and antipyretic efficacy of oral acetaminophen in children.
Journal: Clinical therapeutics
Published: December 12, 2012
Showing 1-11 of 11
Last Updated: 09/26/2026