Edwin Spaans

Liempde, NB, Netherlands

Last Updated: 09/26/2026

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Found 11 publications

A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111.

A first-in-human study evaluating safety, PK, and PD of a novel universal anticoagulant reversal agent, OKL-1111.

Journal: Blood vessels, thrombosis & hemostasis

Published: July 07, 2025

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.

Journal: Clinical pharmacology and therapeutics

Published: January 09, 2019

The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders.

The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders.

Journal: Clinical pharmacology and therapeutics

Published: July 31, 2018

Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Journal: European journal of clinical pharmacology

Published: April 30, 2018

Natural variability of daily physical activity measured by accelerometry in children with a mitochondrial disease.

Natural variability of daily physical activity measured by accelerometry in children with a mitochondrial disease.

Journal: Mitochondrion

Published: February 22, 2018

KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers.

KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers.

Journal: Orphanet journal of rare diseases

Published: June 27, 2017

Pediatric microdose study of [(14)C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept.

Pediatric microdose study of [(14)C]paracetamol to study drug metabolism using accelerated mass spectrometry: proof of concept.

Journal: Clinical pharmacokinetics

Published: September 18, 2014

Adverse events of haloperidol for the treatment of delirium in critically ill children.

Adverse events of haloperidol for the treatment of delirium in critically ill children.

Journal: Intensive care medicine

Published: August 11, 2014

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Published: May 16, 2014

Asenapine Safety, Tolerability, and Pharmacokinetics After Single and Multiple Doses in Healthy Volunteers.

Asenapine Safety, Tolerability, and Pharmacokinetics After Single and Multiple Doses in Healthy Volunteers.

Journal: Clinical pharmacology in drug development

Published: October 01, 2012

Early stage development of the glycine-1 re-uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men.

Early stage development of the glycine-1 re-uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men.

Journal: British journal of clinical pharmacology

Published: December 09, 2011

Showing 1-11 of 11

Last Updated: 09/26/2026