Eeson Rajendra

Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 22 publications

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy.

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy.

Journal: Science advances

Published: June 12, 2026

Deciphering the phenotypic responses to 177Lu-based radioligand therapy to identify efficacious combinations.

Deciphering the phenotypic responses to 177Lu-based radioligand therapy to identify efficacious combinations.

Journal: European journal of nuclear medicine and molecular imaging

Published: March 20, 2026

The pharmacological profile of ART6043, a first-in-class clinical DNA polymerase theta polymerase domain inhibitor potentiating PARP inhibitor efficacy.

The pharmacological profile of ART6043, a first-in-class clinical DNA polymerase theta polymerase domain inhibitor potentiating PARP inhibitor efficacy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: February 06, 2026

Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1.

Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1.

Journal: Journal of medicinal chemistry

Published: December 08, 2025

Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.

Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.

Journal: Journal of medicinal chemistry

Published: September 17, 2025

Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy.

Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy.

Journal: Nucleic acids research

Published: June 27, 2025

Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-based Reporter Assays.

Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-based Reporter Assays.

Journal: Journal of visualized experiments : JoVE

Published: July 01, 2024

Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types.

Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: June 15, 2023

Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells.

Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells.

Journal: Nucleic acids research

Published: May 25, 2023

Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".

Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".

Journal: Journal of medicinal chemistry

Published: February 23, 2023

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.

Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.

Journal: Journal of medicinal chemistry

Published: October 06, 2022

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: September 27, 2022

Showing 1-12 of 22

Last Updated: 09/26/2026