Elaine Y. Chang

Elaine Y. Chang

Obstetrics and Gynecology

22000 Marine View Drive S
Suite 200
Des Moines, WA 98198

Last Updated: 09/26/2026

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Found 10 publications

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.

Journal: Bioorganic & medicinal chemistry letters

Published: September 20, 2024

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

Journal: British journal of pharmacology

Published: December 21, 2023

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

Journal: eLife

Published: July 24, 2021

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Journal: Bioorganic & medicinal chemistry letters

Published: April 07, 2021

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Journal: Journal of medicinal chemistry

Published: March 08, 2021

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.

Journal: Journal of medicinal chemistry

Published: December 01, 2018

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

Journal: Journal of medicinal chemistry

Published: May 09, 2018

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.

Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.

Journal: Cell reports

Published: February 14, 2018

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

Journal: Science (New York, N.Y.)

Published: December 19, 2015

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.

Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: October 30, 2014

Showing 1-10 of 10

Last Updated: 09/26/2026