Elizabeth M. De Lange

Leiden, ZH, Netherlands

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 40 publications

LeiCNS-PK3.2: A physiologically based pharmacokinetic model framework for predicting intracellular concentrations of acyclovir and ganciclovir active metabolites.

LeiCNS-PK3.2: A physiologically based pharmacokinetic model framework for predicting intracellular concentrations of acyclovir and ganciclovir active metabolites.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: December 16, 2025

Longitudinal metabolomic profiling of biogenic amines in plasma and CSF, and their correlation, reveals sex-specific and age changes in TgF344 Alzheimer's disease transgenic and wildtype rats.

Longitudinal metabolomic profiling of biogenic amines in plasma and CSF, and their correlation, reveals sex-specific and age changes in TgF344 Alzheimer's disease transgenic and wildtype rats.

Journal: Fluids and barriers of the CNS

Published: November 21, 2025

Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency.

Simulation-based assessment of the P-glycoprotein expression-activity relationship shows a drug and system dependency.

Journal: Journal of pharmacokinetics and pharmacodynamics

Published: July 22, 2025

Lipidomic fingerprints reveal sex-, age-, and disease-dependent differences in the TgF344-AD transgenic rats.

Lipidomic fingerprints reveal sex-, age-, and disease-dependent differences in the TgF344-AD transgenic rats.

Journal: Metabolomics : Official journal of the Metabolomic Society

Published: April 30, 2025

Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis.

Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: March 11, 2025

Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Reliability of in vitro data for the mechanistic prediction of brain extracellular fluid pharmacokinetics of P-glycoprotein substrates in vivo; are we scaling correctly?

Journal: Journal of pharmacokinetics and pharmacodynamics

Published: July 19, 2024

Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport.

Exploring Kp,uu,BBB values smaller than unity in remoxipride: A physiologically-based CNS model approach highlighting brain metabolism in drugs with passive blood-brain barrier transport.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: May 30, 2024

CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.

CNS Viral Infections-What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches.

Journal: CNS drugs

Published: March 10, 2024

Safety and transfer of veterinary drugs from substrate to black soldier fly larvae.

Safety and transfer of veterinary drugs from substrate to black soldier fly larvae.

Journal: Animal : an international journal of animal bioscience

Published: February 23, 2024

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.

Journal: Pharmaceutical research

Published: May 16, 2023

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: January 21, 2023

Biochemical reaction network topology defines dose-dependent Drug-Drug interactions.

Biochemical reaction network topology defines dose-dependent Drug-Drug interactions.

Journal: Computers in biology and medicine

Published: September 20, 2022

Showing 1-12 of 40

Last Updated: 09/26/2026