Emanuele Gabellieri

Lausanne, VD, Switzerland

Last Updated: 09/26/2026

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Found 10 publications

Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo.

Elimination of tau tangles and soluble aggregates with the small molecule ACI-16664 prevents neurodegeneration in vivo.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: December 09, 2025

Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.

Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.

Journal: Bioorganic & medicinal chemistry

Published: September 09, 2021

PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.

PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.

Journal: Journal of medicinal chemistry

Published: August 30, 2021

Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.

Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.

Journal: European journal of medicinal chemistry

Published: April 17, 2020

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.

Journal: European journal of nuclear medicine and molecular imaging

Published: December 11, 2018

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.

Journal: Journal of medicinal chemistry

Published: February 19, 2016

A stereoselective approach to peptidomimetic BACE1 inhibitors.

A stereoselective approach to peptidomimetic BACE1 inhibitors.

Journal: European journal of medicinal chemistry

Published: May 29, 2013

BACE1 inhibitors: a head group scan on a series of amides.

BACE1 inhibitors: a head group scan on a series of amides.

Journal: Bioorganic & medicinal chemistry letters

Published: March 22, 2013

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.

Journal: Journal of medicinal chemistry

Published: November 14, 2012

Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.

Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.

Journal: Bioorganic & medicinal chemistry letters

Published: September 11, 2012

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Last Updated: 09/26/2026