Emma T. Van Der Westhuizen

Melbourne, VIC 3052, Australia

Last Updated: 09/26/2026

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Found 22 publications

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

Journal: ACS chemical neuroscience

Published: June 30, 2026

Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.

Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.

Journal: European journal of medicinal chemistry

Published: April 24, 2023

Single nucleotide variations encoding missense mutations in G protein-coupled receptors may contribute to autism.

Single nucleotide variations encoding missense mutations in G protein-coupled receptors may contribute to autism.

Journal: British journal of pharmacology

Published: September 26, 2022

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Journal: eLife

Published: September 15, 2022

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.

Journal: British journal of pharmacology

Published: July 06, 2022

Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.

Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.

Journal: ACS chemical neuroscience

Published: April 05, 2022

Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.

Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.

Journal: ACS chemical neuroscience

Published: August 05, 2021

Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor.

Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor.

Journal: ACS chemical neuroscience

Published: November 16, 2020

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.

Journal: Frontiers in pharmacology

Published: September 15, 2020

Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.

Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.

Journal: ChemMedChem

Published: July 21, 2020

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.

Journal: Nature communications

Published: April 18, 2020

Crystal structure of the M5 muscarinic acetylcholine receptor.

Crystal structure of the M5 muscarinic acetylcholine receptor.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: November 28, 2019

Showing 1-12 of 22

Last Updated: 09/26/2026