Emmanouil Metzakopian

Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 37 publications

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.

Journal: Neuron

Published: October 22, 2024

Correction: Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution.

Correction: Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution.

Journal: Molecular neurodegeneration

Published: March 26, 2024

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport.

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport.

Journal: Cell reports

Published: February 14, 2024

Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective.

Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective.

Journal: Cell death & disease

Published: June 26, 2023

Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution.

Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution.

Journal: Molecular neurodegeneration

Published: May 16, 2023

Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.

Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.

Journal: Neuroscience research

Published: April 03, 2023

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.

Journal: Science advances

Published: January 13, 2023

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.

Journal: Scientific reports

Published: December 11, 2022

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

Journal: The EMBO journal

Published: November 29, 2022

Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson's Disease Independent of Mutations in MAPT.

Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson's Disease Independent of Mutations in MAPT.

Journal: Metabolites

Published: November 01, 2022

Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.

Publisher Correction: UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.

Journal: Nature genetics

Published: June 14, 2022

Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression.

Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression.

Journal: Cell reports methods

Published: November 10, 2021

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Last Updated: 09/26/2026