Erik M. De Clercq

Leuven, VLG 3000, Belgium

Last Updated: 09/26/2026

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Found 325 publications

Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1.

Rational design of dual-site NNRTIs based on 2,4,5-trisubstituted pyrimidine scaffold for potent inhibition of resistant HIV-1.

Journal: European journal of medicinal chemistry

Published: June 15, 2026

On the Verge of the 3000th Publication: Reflections on Deceptions, Successes and Perspectives.

On the Verge of the 3000th Publication: Reflections on Deceptions, Successes and Perspectives.

Journal: Molecules (Basel, Switzerland)

Published: May 20, 2026

Correction to "Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence".

Correction to "Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence".

Journal: Journal of medicinal chemistry

Published: April 20, 2026

Discovery of Potent 1,2,4-Triazole-Derived HIV Capsid Modulators with Dual-Stage Antiviral Activity via Targeting the Unexplored GTNQ Sub-Pocket Using a Multi-Site Binding Strategy.

Discovery of Potent 1,2,4-Triazole-Derived HIV Capsid Modulators with Dual-Stage Antiviral Activity via Targeting the Unexplored GTNQ Sub-Pocket Using a Multi-Site Binding Strategy.

Journal: Journal of medicinal chemistry

Published: April 02, 2026

Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence.

Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence.

Journal: Journal of medicinal chemistry

Published: March 30, 2026

Geographical and temporal trends of HIV-1 subtypes and drug resistance in China: a nationwide study over two decades (2003-2024).

Geographical and temporal trends of HIV-1 subtypes and drug resistance in China: a nationwide study over two decades (2003-2024).

Journal: The Journal of general virology

Published: February 02, 2026

Tribute to Paul F. Torrence, a brilliant chemist switching from polynucleotides to nucleosides, oligonucleotides, and back to nucleosides.

Tribute to Paul F. Torrence, a brilliant chemist switching from polynucleotides to nucleosides, oligonucleotides, and back to nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids

Published: January 08, 2026

Correction to "Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles".

Correction to "Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles".

Journal: Journal of medicinal chemistry

Published: October 23, 2025

Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles.

Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles.

Journal: Journal of medicinal chemistry

Published: October 20, 2025

Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluation.

Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluation.

Journal: Bioorganic chemistry

Published: October 18, 2025

Pioneering Role of T.C. Merigan in the Treatment of Various Virus Infections.

Pioneering Role of T.C. Merigan in the Treatment of Various Virus Infections.

Journal: Molecules (Basel, Switzerland)

Published: October 08, 2025

Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles.

Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2,4,6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles.

Journal: Journal of medicinal chemistry

Published: September 17, 2025

Showing 1-12 of 325

Last Updated: 09/26/2026