Ervin Welker

Szeged, CS 6726, Hungary

Last Updated: 09/26/2026

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Found 24 publications

Disrupting pegRNA intramolecular complementarity via PBS and spacer sequence alterations can enhance prime editing efficiency.

Disrupting pegRNA intramolecular complementarity via PBS and spacer sequence alterations can enhance prime editing efficiency.

Journal: Nucleic acids research
Published: December 06, 2024

A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets.

A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets.

Journal: Nature communications
Published: August 08, 2022

Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs.

Position-dependent sequence motif preferences of SpCas9 are largely determined by scaffold-complementary spacer motifs.

Journal: Nucleic acids research
Published: July 23, 2022

SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e.

SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e.

Journal: Nature communications
Published: April 26, 2022

Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin.

Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin.

Journal: Membranes
Published: November 08, 2021

PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells.

PEAR, a flexible fluorescent reporter for the identification and enrichment of successfully prime edited cells.

Journal: eLife
Published: April 16, 2021

BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors.

BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors.

Journal: Nature communications
Published: November 10, 2020

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.

The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.

Journal: Scientific reports
Published: August 30, 2020

A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs.

A method for characterizing Cas9 variants via a one-million target sequence library of self-targeting sgRNAs.

Journal: Nucleic acids research
Published: December 11, 2019

Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases.

Improved LbCas12a variants with altered PAM specificities further broaden the genome targeting range of Cas12a nucleases.

Journal: Nucleic acids research
Published: June 25, 2019

Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs.

Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs.

Journal: Nature communications
Published: June 25, 2019

Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants.

Mb- and FnCpf1 nucleases are active in mammalian cells: activities and PAM preferences of four wild-type Cpf1 nucleases and of their altered PAM specificity variants.

Journal: Nucleic acids research
Published: February 15, 2018
Showing 1-12 of 24

Last Updated: 09/26/2026