Fa-jun Nan

State Key Laboratory Of Drug Research
Shanghai, China

Last Updated: 09/26/2026

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Found 43 publications

Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers.

Biomimetic Total Synthesis of Dispirocochlearoids A-C and Related Ganoderma Meroterpenoid Dimers.

Journal: Organic letters

Published: December 12, 2025

HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models.

HDAC inhibitor GCJ-490A modulates tumor microenvironment and synergizes with PD-1 antibody against breast and lung cancers in syngeneic murine models.

Journal: Acta pharmacologica Sinica

Published: March 31, 2025

Author Correction: Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

Author Correction: Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

Journal: Nature communications

Published: July 05, 2023

Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation.

Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation.

Journal: Journal of medicinal chemistry

Published: April 13, 2023

GPR84 regulates pulmonary inflammation by modulating neutrophil functions.

GPR84 regulates pulmonary inflammation by modulating neutrophil functions.

Journal: Acta pharmacologica Sinica

Published: January 25, 2023

Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

Journal: Nature communications

Published: December 02, 2022

Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis.

Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis.

Journal: Journal of medicinal chemistry

Published: February 23, 2022

GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.

GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.

Journal: Acta pharmacologica Sinica

Published: July 13, 2021

Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate.

Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate.

Journal: Journal of medicinal chemistry

Published: April 30, 2021

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma.

Journal: Acta pharmacologica Sinica

Published: December 07, 2020

Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.

Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists.

Journal: Journal of medicinal chemistry

Published: December 03, 2020

Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue.

Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue.

Journal: Acta pharmacologica Sinica

Published: April 17, 2020

Showing 1-12 of 43

Last Updated: 09/26/2026