Fabio Zuccotto

Dow Street, DD1 5EH
Dundee, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 35 publications

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Journal: Journal of medicinal chemistry

Published: June 02, 2026

Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.

Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.

Journal: Journal of medicinal chemistry

Published: August 01, 2025

Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments.

Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments.

Journal: ChemMedChem

Published: January 26, 2024

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.

Journal: Science translational medicine

Published: December 13, 2023

Short-course combination treatment for experimental chronic Chagas disease.

Short-course combination treatment for experimental chronic Chagas disease.

Journal: Science translational medicine

Published: December 13, 2023

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.

Journal: Journal of medicinal chemistry

Published: November 10, 2023

Accurate prediction of dynamic protein-ligand binding using P-score ranking.

Accurate prediction of dynamic protein-ligand binding using P-score ranking.

Journal: Journal of computational chemistry

Published: October 20, 2023

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 28, 2023

Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.

Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.

Journal: Nature

Published: July 04, 2023

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.

Journal: Nature communications

Published: April 12, 2022

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Journal: Journal of medicinal chemistry

Published: March 18, 2022

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Journal: Journal of medicinal chemistry

Published: December 15, 2021

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Last Updated: 09/26/2026