Fabrizio Chiti

Fabrizio Chiti

Florence, 50134, Italy

Last Updated: 09/26/2026

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Found 107 publications

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.

Journal: Journal of medicinal chemistry

Published: May 27, 2026

PBMC DEG/miRNA biomarkers of TDP-43 pathology in ALS.

PBMC DEG/miRNA biomarkers of TDP-43 pathology in ALS.

Journal: Neurobiology of disease

Published: April 01, 2026

Evaluation of intrinsic Young's modulus and stiffening effect of trodusquemine in phase-separated supported lipid bilayers.

Evaluation of intrinsic Young's modulus and stiffening effect of trodusquemine in phase-separated supported lipid bilayers.

Journal: Journal of colloid and interface science

Published: December 10, 2025

An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.

An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: July 07, 2025

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome-linked mutations.

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome-linked mutations.

Journal: The FEBS journal

Published: July 03, 2025

Engineering a dimeric single-domain antibody for improved detection and neutralization of amyloid-β oligomers.

Engineering a dimeric single-domain antibody for improved detection and neutralization of amyloid-β oligomers.

Journal: Communications biology

Published: June 19, 2025

Berberine mitigates neurotoxicity of misfolded protein oligomers by interacting with the cell membrane and subsequent internalization, without altering their structure.

Berberine mitigates neurotoxicity of misfolded protein oligomers by interacting with the cell membrane and subsequent internalization, without altering their structure.

Journal: International journal of biological macromolecules

Published: June 10, 2025

Evolving concepts of the protein universe.

Evolving concepts of the protein universe.

Journal: iScience

Published: March 24, 2025

Improving our understanding of the biology of aging: findings from the Age-It Research Program.

Improving our understanding of the biology of aging: findings from the Age-It Research Program.

Journal: The journals of gerontology. Series B, Psychological sciences and social sciences

Published: February 17, 2025

Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.

Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.

Journal: Cell & bioscience

Published: February 06, 2025

Fibrillar structures detected by AFM in the cerebrospinal fluid of patients affected by Alzheimer's disease and other neurological conditions.

Fibrillar structures detected by AFM in the cerebrospinal fluid of patients affected by Alzheimer's disease and other neurological conditions.

Journal: Archives of biochemistry and biophysics

Published: January 07, 2025

Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation.

Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation.

Journal: Genome biology

Published: December 23, 2024

Showing 1-12 of 107

Last Updated: 09/26/2026