Fady Baselious

Halle, NI, Germany

Last Updated: 09/26/2026

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Found 11 publications

Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life.

Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life.

Journal: Molecular biology and evolution

Published: November 17, 2025

In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors.

In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors.

Journal: Computers in biology and medicine

Published: March 13, 2025

4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells.

4-(Pyrazolyl)benzenesulfonamide Ureas as Carbonic Anhydrases Inhibitors and Hypoxia-Mediated Chemo-Sensitizing Agents in Colorectal Cancer Cells.

Journal: Journal of medicinal chemistry

Published: November 17, 2024

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity.

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity.

Journal: Journal of medicinal chemistry

Published: September 20, 2024

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Journal: Archiv der Pharmazie

Published: June 14, 2024

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells.

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells.

Journal: Archiv der Pharmazie

Published: May 31, 2024

Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors.

Design, synthesis, and biological evaluation of dinaciclib and CAN508 hybrids as CDK inhibitors.

Journal: Drug development research

Published: February 23, 2024

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Journal: International journal of molecular sciences

Published: December 11, 2023

Utilization of AlphaFold models for drug discovery: Feasibility and challenges. Histone deacetylase 11 as a case study.

Utilization of AlphaFold models for drug discovery: Feasibility and challenges. Histone deacetylase 11 as a case study.

Journal: Computers in biology and medicine

Published: August 31, 2023

Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors.

Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors.

Journal: Bioorganic chemistry

Published: January 31, 2023

Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease.

Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease.

Journal: Future medicinal chemistry

Published: August 03, 2022

Showing 1-11 of 11

Last Updated: 09/26/2026