Federico Falchi

Genoa, 16163, Italy

Last Updated: 09/26/2026

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Found 38 publications

Targeting RAD51-BRCA2 Interaction to Enhance Synthetic Lethality with Olaparib in Pancreatic Cancer: Development of a Novel Phenyl Furan-Quinoline-Carboxylic Acid Series.

Targeting RAD51-BRCA2 Interaction to Enhance Synthetic Lethality with Olaparib in Pancreatic Cancer: Development of a Novel Phenyl Furan-Quinoline-Carboxylic Acid Series.

Journal: ACS medicinal chemistry letters

Published: November 26, 2025

Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors.

Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors.

Journal: Journal of medicinal chemistry

Published: August 08, 2025

Morphological inhibitors of aggregation-prone amyloid-β conformers: A computational exploration.

Morphological inhibitors of aggregation-prone amyloid-β conformers: A computational exploration.

Journal: Computers in biology and medicine

Published: February 10, 2025

Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector.

Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector.

Journal: Journal of medicinal chemistry

Published: February 10, 2025

Alkyl Tail Variation on Chalcone-Based Quaternary Pyridinium Salts as Rule-of-Thumb for Antimicrobial Activity.

Alkyl Tail Variation on Chalcone-Based Quaternary Pyridinium Salts as Rule-of-Thumb for Antimicrobial Activity.

Journal: Archiv der Pharmazie

Published: October 21, 2024

Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.

Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity.

Journal: Cell death discovery

Published: October 14, 2024

Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii.

Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii.

Journal: Frontiers in microbiology

Published: September 24, 2024

Correction to "Novel Antiproliferative Chimeric Compounds with Marked Histone Deacetylase Inhibitory Activity".

Correction to "Novel Antiproliferative Chimeric Compounds with Marked Histone Deacetylase Inhibitory Activity".

Journal: ACS medicinal chemistry letters

Published: June 24, 2024

Probing allosteric communication with combined molecular dynamics simulations and network analysis.

Probing allosteric communication with combined molecular dynamics simulations and network analysis.

Journal: Current opinion in structural biology

Published: January 31, 2024

Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5.

Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5.

Journal: Journal of medicinal chemistry

Published: July 13, 2023

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives.

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives.

Journal: Journal of medicinal chemistry

Published: April 04, 2022

Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach.

Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach.

Journal: Journal of medicinal chemistry

Published: November 30, 2021

Showing 1-12 of 38

Last Updated: 09/26/2026