Federico M. Ruiz

Madrid, MD 28040, Spain

Last Updated: 09/26/2026

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Found 24 publications

The structures of ecteinascidin anticancer agents bound to DNA shed light on their mechanism of action.

The structures of ecteinascidin anticancer agents bound to DNA shed light on their mechanism of action.

Journal: Nucleic acids research
Published: December 15, 2025

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions.

Journal: Nature communications
Published: August 18, 2024

Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation.

Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation.

Journal: Frontiers in oncology
Published: July 09, 2024

The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function.

The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function.

Journal: Structure (London, England : 1993)
Published: November 16, 2023

Conserved GTPase mechanism in bacterial FtsZ and archaeal tubulin filaments.

Conserved GTPase mechanism in bacterial FtsZ and archaeal tubulin filaments.

Journal: The FEBS journal
Published: September 21, 2022

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status.

Small molecule MMRi62 targets MDM4 for degradation and induces leukemic cell apoptosis regardless of p53 status.

Journal: Frontiers in oncology
Published: April 30, 2022

Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin.

Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin.

Journal: Biomolecules
Published: November 16, 2021

FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics.

FtsZ filament structures in different nucleotide states reveal the mechanism of assembly dynamics.

Journal: PLoS biology
Published: November 12, 2021

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery.

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery.

Journal: Journal of medicinal chemistry
Published: April 28, 2021

Structural Characterization of TssL from Acinetobacter baumannii: a Key Component of the Type VI Secretion System.

Structural Characterization of TssL from Acinetobacter baumannii: a Key Component of the Type VI Secretion System.

Journal: Journal of bacteriology
Published: April 12, 2020

The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.

The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair.

Journal: Nucleic acids research
Published: January 09, 2020

Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus.

Nucleotide-induced folding of cell division protein FtsZ from Staphylococcus aureus.

Journal: The FEBS journal
Published: September 06, 2019
Showing 1-12 of 24

Last Updated: 09/26/2026