Last Updated: 09/26/2026
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Found 30 publications
Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice.
Journal: The Journal of clinical investigation
Published: July 09, 2024
Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration.
Journal: Investigative ophthalmology & visual science
Published: April 25, 2023
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
Journal: American journal of physiology. Lung cellular and molecular physiology
Published: February 16, 2022
ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
Journal: Nature chemical biology
Published: December 26, 2020
Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.
Journal: International journal of molecular sciences
Published: July 17, 2020
Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.
Journal: ACS chemical biology
Published: October 15, 2019
Nicotinic acetylcholine receptor signaling regulates inositol-requiring enzyme 1α activation to protect β-cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress.
Journal: Journal of diabetes investigation
Published: September 20, 2019
Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.
Journal: Molecular metabolism
Published: September 11, 2019
Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: May 19, 2019
Small Molecules to Improve ER Proteostasis in Disease.
Journal: Trends in pharmacological sciences
Published: February 04, 2019
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
Journal: PloS one
Published: August 23, 2018
Last Updated: 09/26/2026