Flavia Varano
Via Ugo Schiff, 6, FI
Sesto Fiorentino, 50019, Italy
Sesto Fiorentino, 50019, Italy
Last Updated: 09/26/2026
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Found 49 publications
Design, synthesis, and pharmacological evaluation of thiazolo[5,4-d]pyrimidines hybridized with lipoic acid or catechol. Novel A2A adenosine receptor antagonists in neuroinflammatory diseases.
Journal: Bioorganic chemistry
Published: May 15, 2026
Structural Simplification from Tricyclic to Bicyclic Scaffolds: A Long-Term Investigation in the Field of Adenosine Receptor Antagonists.
Journal: Cells
Published: July 10, 2025
Adenosine A2A receptor blockade promotes oligodendrocyte differentiation and myelination: Highlighting the potency of an edaravone-conjugated A2A receptor antagonist.
Journal: Neuropharmacology
Published: July 08, 2025
8-Amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives hybridized with antioxidants: new highly potent and selective human A2A adenosine receptor antagonists as useful agents against cerebral ischemia.
Journal: Bioorganic chemistry
Published: June 18, 2025
Protection From Demyelination by the Novel Adenosine Dual A2A/A2B Receptor Antagonist P626 in EAE and Cultured Oligodendrocyte Precursor Cells.
Journal: Journal of cellular and molecular medicine
Published: April 13, 2025
Repurposing the amino-3,5-dicyanopyridine scaffold from adenosine receptor ligands to carbonic anhydrase activators.
Journal: European journal of medicinal chemistry
Published: January 09, 2025
The potent and selective adenosine A2AR antagonists P400 and P625 protect against symptoms in autoimmune experimental encephalomyelitis by attenuating neuroinflammation and demyelination.
Journal: Neuropharmacology
Published: December 24, 2024
Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta.
Journal: Pharmaceuticals (Basel, Switzerland)
Published: December 06, 2023
Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus.
Journal: Biomolecules
Published: March 24, 2023
"Dual Anta-Inhibitors" of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies.
Journal: Pharmaceuticals (Basel, Switzerland)
Published: December 21, 2022
CK1 delta inhibition: an emerging strategy to combat neurodegenerative diseases.
Journal: Future medicinal chemistry
Published: July 08, 2022
4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives.
Journal: Pharmaceuticals (Basel, Switzerland)
Published: March 01, 2022
Last Updated: 09/26/2026