Florian Kloss

Adolf Reichwein Str. 23
Jena, TH 07745, Germany

Last Updated: 09/26/2026

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Found 36 publications

Hydride-Meisenheimer metabolism in mammals - scope of an overlooked biotransformation pathway.

Hydride-Meisenheimer metabolism in mammals - scope of an overlooked biotransformation pathway.

Journal: Bioorganic chemistry

Published: February 28, 2026

First-in-human study of the benzothiazinone and DprE1 inhibitor BTZ-043, a novel drug candidate for the treatment of Tuberculosis.

First-in-human study of the benzothiazinone and DprE1 inhibitor BTZ-043, a novel drug candidate for the treatment of Tuberculosis.

Journal: JAC-antimicrobial resistance

Published: February 03, 2025

Pilot Scale Production of a F420 Precursor Under Microaerobic Conditions.

Pilot Scale Production of a F420 Precursor Under Microaerobic Conditions.

Journal: Biotechnology journal

Published: December 19, 2024

Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones.

Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones.

Journal: European journal of medicinal chemistry

Published: June 25, 2024

Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction.

Deazaflavin metabolite produced by endosymbiotic bacteria controls fungal host reproduction.

Journal: The ISME journal

Published: February 16, 2024

Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution.

Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution.

Journal: Communications chemistry

Published: January 16, 2024

In Vitro Antibacterial Activity of Microbial Natural Products against Bacterial Pathogens of Veterinary and Zoonotic Relevance.

In Vitro Antibacterial Activity of Microbial Natural Products against Bacterial Pathogens of Veterinary and Zoonotic Relevance.

Journal: Antibiotics (Basel, Switzerland)

Published: December 07, 2023

Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.

Safety, bactericidal activity, and pharmacokinetics of the antituberculosis drug candidate BTZ-043 in South Africa (PanACEA-BTZ-043-02): an open-label, dose-expansion, randomised, controlled, phase 1b/2a trial.

Journal: The Lancet. Microbe

Published: October 26, 2023

Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones.

Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones.

Journal: European journal of medicinal chemistry

Published: October 17, 2023

Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents.

Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents.

Journal: Archiv der Pharmazie

Published: July 05, 2023

Prenylated Isoflavanones with Antimicrobial Potential from the Root Bark of Dalbergia melanoxylon.

Prenylated Isoflavanones with Antimicrobial Potential from the Root Bark of Dalbergia melanoxylon.

Journal: Metabolites

Published: April 21, 2023

Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model.

Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model.

Journal: Antimicrobial agents and chemotherapy

Published: March 28, 2023

Showing 1-12 of 36

Last Updated: 09/26/2026