Florian Thaler

Via Adamello 16
Milan, 20139, Italy

Last Updated: 09/26/2026

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Found 14 publications

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Journal: Future medicinal chemistry

Published: July 20, 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

Journal: Journal of medicinal chemistry

Published: February 11, 2017

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

Journal: Journal of medicinal chemistry

Published: February 11, 2017

Compounds and methods for inhibiting histone demethylases: a patent evaluation of US20160102096A1.

Compounds and methods for inhibiting histone demethylases: a patent evaluation of US20160102096A1.

Journal: Expert opinion on therapeutic patents

Published: October 13, 2016

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Journal: Journal of medicinal chemistry

Published: December 26, 2015

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

Journal: European journal of medicinal chemistry

Published: August 04, 2015

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

Journal: European journal of medicinal chemistry

Published: June 12, 2014

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Journal: Journal of medicinal chemistry

Published: June 12, 2014

Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.

Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.

Journal: ChemMedChem

Published: April 15, 2014

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.

Journal: European journal of medicinal chemistry

Published: November 30, 2012

Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications.

Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications.

Journal: Pharmaceutical patent analyst

Published: March 01, 2012

Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity.

Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity.

Journal: ChemMedChem

Published: January 13, 2012

Showing 1-12 of 14

Last Updated: 09/26/2026