Francesco Miceli
Naples, Italy
Last Updated: 09/26/2026
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Found 47 publications
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators.
Journal: Angewandte Chemie (International ed. in English)
Published: February 21, 2026
Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation.
Journal: Nature communications
Published: August 20, 2025
Kv7.2 loss-of-function causes early hyperexcitability and network remodelling.
Journal: Brain : a journal of neurology
Published: July 24, 2025
The fast-dissociating D2 antagonist antipsychotic JNJ-37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment.
Journal: British journal of pharmacology
Published: December 23, 2024
Constitutive opening of the Kv7.2 pore activation gate causes KCNQ2-developmental encephalopathy.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: November 27, 2024
In Silico Assisted Identification, Synthesis, and In Vitro Pharmacological Characterization of Potent and Selective Blockers of the Epilepsy-Associated KCNT1 Channel.
Journal: Journal of medicinal chemistry
Published: May 23, 2024
Kv7 channel activation reduces brain endothelial cell permeability and prevents kainic acid-induced blood-brain barrier damage.
Journal: American journal of physiology. Cell physiology
Published: January 29, 2024
Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Published: October 10, 2023
Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity.
Journal: Journal of medicinal chemistry
Published: August 16, 2022
Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: April 04, 2022
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism.
Journal: EBioMedicine
Published: January 22, 2022
Last Updated: 09/26/2026