Francis J. Mussai

Pediatric Hematology Oncology

Pediatric Oncology Johns Hopkins Hospital
Cmsc 800, 600 N. Wolfe Street
Baltimore, MD 21287

Last Updated: 09/26/2026

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Found 38 publications

The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase 2 single-arm, open-label trial.

The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase 2 single-arm, open-label trial.

Journal: Journal of leukocyte biology

Published: December 12, 2025

Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma.

Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma.

Journal: Journal of experimental & clinical cancer research : CR

Published: June 25, 2025

The immune landscape of pediatric (extra)cranial solid tumors: A systematic review and integration of immunohistochemistry and single-cell RNA sequencing data.

The immune landscape of pediatric (extra)cranial solid tumors: A systematic review and integration of immunohistochemistry and single-cell RNA sequencing data.

Journal: European journal of cancer (Oxford, England : 1990)

Published: June 06, 2025

PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults.

PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults.

Journal: Frontiers in oncology

Published: September 18, 2023

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.

Journal: EMBO reports

Published: October 12, 2022

A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial.

A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial.

Journal: British journal of haematology

Published: August 24, 2022

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.

Journal: Blood advances

Published: June 06, 2022

Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.

Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.

Journal: Cancer immunology, immunotherapy : CII

Published: February 18, 2022

Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion.

Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion.

Journal: BioMed research international

Published: January 19, 2022

G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment.

G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment.

Journal: Clinical & translational immunology

Published: November 09, 2021

Targeted inhibitors and antibody immunotherapies: Novel therapies for paediatric leukaemia and lymphoma.

Targeted inhibitors and antibody immunotherapies: Novel therapies for paediatric leukaemia and lymphoma.

Journal: European journal of cancer (Oxford, England : 1990)

Published: September 28, 2021

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.

Journal: Cancer immunology, immunotherapy : CII

Published: June 23, 2021

Showing 1-12 of 38

Last Updated: 09/26/2026