Francis X. Wilson

Summit Therapeutics Plc, 136a Eastern Avenue, Milton Park
Abingdon, ENG OX144SB, United Kingdom

Last Updated: 09/26/2026

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Found 13 publications

Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.

Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.

Journal: Bioorganic & medicinal chemistry

Published: April 04, 2022

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Journal: European journal of medicinal chemistry

Published: December 01, 2020

Targeted microbiome-sparing antibiotics.

Targeted microbiome-sparing antibiotics.

Journal: Drug discovery today

Published: November 02, 2020

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model.

Journal: Tetrahedron

Published: July 28, 2020

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

Journal: ACS medicinal chemistry letters

Published: July 20, 2020

2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.

2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.

Journal: Journal of medicinal chemistry

Published: June 20, 2020

Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.

Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.

Journal: Journal of medicinal chemistry

Published: October 11, 2019

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Journal: Angewandte Chemie (International ed. in English)

Published: September 27, 2019

Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.

Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.

Journal: Bioorganic chemistry

Published: June 12, 2019

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.

Journal: PloS one

Published: June 10, 2015

The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership.

The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership.

Journal: MedChemComm

Published: June 05, 2015

Second-generation compound for the modulation of utrophin in the therapy of DMD.

Second-generation compound for the modulation of utrophin in the therapy of DMD.

Journal: Human molecular genetics

Published: March 09, 2015

Showing 1-12 of 13

Last Updated: 09/26/2026