Francisco-javier Gamo

GlaxoSmithKline R&D
Tres Cantos, MD 28760, Spain

Last Updated: 09/26/2026

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Found 60 publications

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation.

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity against the Human Malaria Parasite Plasmodium falciparum via Polypharmacological Inhibition of PfArk1 and Hemozoin Formation.

Journal: ACS chemical biology

Published: June 13, 2026

The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria.

The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage Plasmodium falciparum in healthy adults with experimental malaria.

Journal: Science translational medicine

Published: June 10, 2026

Correction: Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.

Correction: Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.

Journal: PLoS pathogens

Published: December 29, 2025

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.

Journal: bioRxiv : the preprint server for biology

Published: August 13, 2025

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation.

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation.

Journal: bioRxiv : the preprint server for biology

Published: August 12, 2025

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.

Journal: Research square

Published: December 09, 2024

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

Journal: Science (New York, N.Y.)

Published: November 28, 2024

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.

Journal: NPJ drug discovery

Published: November 07, 2024

Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action.

Plasmodium SEY1 is a novel druggable target that contributes to imidazolopiperazine mechanism of action.

Journal: Research square

Published: October 14, 2024

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367.

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367.

Journal: British journal of clinical pharmacology

Published: October 04, 2024

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367.

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367.

Journal: British journal of clinical pharmacology

Published: October 04, 2024

Unravelling the mode of action of the Tres Cantos Antimalarial Set (TCAMS): investigating the mechanism of potent antimalarial compounds potentially targeting the human serotonin receptor.

Unravelling the mode of action of the Tres Cantos Antimalarial Set (TCAMS): investigating the mechanism of potent antimalarial compounds potentially targeting the human serotonin receptor.

Journal: Malaria journal

Published: May 29, 2024

Showing 1-12 of 60

Last Updated: 09/26/2026