Francois Debaene

16 Rue D'Ankara
Strasbourg, 67000, France

Last Updated: 09/26/2026

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Found 19 publications

Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM.

Deciphering molecular determinants of GPBAR1-Gs protein interactions by HDX-MS and cryo-EM.

Journal: Scientific reports

Published: May 09, 2025

Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues.

Screening approaches for the identification of Nrf2-Keap1 protein-protein interaction inhibitors targeting hot spot residues.

Journal: SLAS discovery : advancing life sciences R & D

Published: June 05, 2023

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.

Journal: Molecular cancer therapeutics

Published: November 04, 2022

The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein-Protein Interface of Homodimeric tRNA-Guanine Transglycosylase.

The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein-Protein Interface of Homodimeric tRNA-Guanine Transglycosylase.

Journal: ACS chemical biology

Published: November 09, 2020

A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state.

A small-molecule inhibitor of lectin-like oxidized LDL receptor-1 acts by stabilizing an inactive receptor tetramer state.

Journal: Communications chemistry

Published: January 10, 2020

Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches.

Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches.

Journal: mAbs

Published: September 22, 2017

Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.

Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.

Journal: PloS one

Published: February 21, 2017

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.

Journal: Expert review of proteomics

Published: December 15, 2015

What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt.

What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt.

Journal: ACS chemical biology

Published: May 08, 2015

CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability.

CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability.

Journal: Bioconjugate chemistry

Published: January 24, 2015

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies.

Journal: Journal of mass spectrometry : JMS

Published: July 28, 2014

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

Functional and structural characterization of 2-amino-4-phenylthiazole inhibitors of the HIV-1 nucleocapsid protein with antiviral activity.

Journal: ACS chemical biology

Published: July 03, 2014

Showing 1-12 of 19

Last Updated: 09/26/2026