Francois Jean

Vancouver, BC, Canada

Last Updated: 09/26/2026

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Found 30 publications

A reversible broad-spectrum antiviral targets the human V-ATPase VO domain.

A reversible broad-spectrum antiviral targets the human V-ATPase VO domain.

Journal: Research square
Published: June 12, 2026

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.

Journal: Emerging microbes & infections
Published: January 30, 2026

Autophagy-enhancing strategies to promote intestinal viral resistance and mucosal barrier function in SARS-CoV-2 infection.

Autophagy-enhancing strategies to promote intestinal viral resistance and mucosal barrier function in SARS-CoV-2 infection.

Journal: Autophagy reports
Published: June 12, 2025

No Evidence of Anti-Influenza Nucleoprotein Antibodies in Retail Milk from Across Canada (April-July 2024).

No Evidence of Anti-Influenza Nucleoprotein Antibodies in Retail Milk from Across Canada (April-July 2024).

Journal: Viral immunology
Published: June 06, 2025

From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.

From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants.

Journal: Journal of medicinal chemistry
Published: March 31, 2025

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Journal: European journal of medicinal chemistry
Published: February 18, 2025

Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance.

Functional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance.

Journal: The Journal of infectious diseases
Published: November 15, 2024

Longitudinal screening of retail milk from Canadian provinces reveals no detections of influenza A virus RNA (April-July 2024): leveraging a newly established pan-Canadian network for responding to emerging viruses.

Longitudinal screening of retail milk from Canadian provinces reveals no detections of influenza A virus RNA (April-July 2024): leveraging a newly established pan-Canadian network for responding to emerging viruses.

Journal: Canadian journal of microbiology
Published: September 27, 2024

Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals.

Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals.

Journal: Antiviral research
Published: February 05, 2024

Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication.

Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication.

Journal: ChemMedChem
Published: August 23, 2023

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.

A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.

Journal: Emerging microbes & infections
Published: August 09, 2023

Synthetic Analogs of the Sponge Sesterterpenoid Alotaketal C are Potent Inhibitors of SARS-CoV-2 Omicron BA.1 and BA.5 Infections of Human Lung Cells.

Synthetic Analogs of the Sponge Sesterterpenoid Alotaketal C are Potent Inhibitors of SARS-CoV-2 Omicron BA.1 and BA.5 Infections of Human Lung Cells.

Journal: Organic letters
Published: June 26, 2023
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Last Updated: 09/26/2026