Frank J. Dekker

Groningen, GR 9713AV, Netherlands

Last Updated: 09/26/2026

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Found 95 publications

Development of Indole-3-yl-methylene-thiobarbital Derivatives as Inhibitors of HDAC8 Enzyme Activity.

Development of Indole-3-yl-methylene-thiobarbital Derivatives as Inhibitors of HDAC8 Enzyme Activity.

Journal: Journal of medicinal chemistry

Published: July 06, 2026

Discovery of Furan-2-Carboxylic Acid Derivatives as Novel D-Dopachrome Tautomerase (D-DT) and Macrophage Migration Inhibitory Factor-1 (MIF-1) Dual Inhibitors.

Discovery of Furan-2-Carboxylic Acid Derivatives as Novel D-Dopachrome Tautomerase (D-DT) and Macrophage Migration Inhibitory Factor-1 (MIF-1) Dual Inhibitors.

Journal: Journal of medicinal chemistry

Published: March 02, 2026

Correction to "Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells".

Correction to "Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells".

Journal: Journal of medicinal chemistry

Published: March 10, 2025

Novel 15-lipoxygenase-1 inhibitor protects cells from RSL3-induced cell death.

Novel 15-lipoxygenase-1 inhibitor protects cells from RSL3-induced cell death.

Journal: European journal of medicinal chemistry

Published: December 20, 2024

Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors.

Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors.

Journal: Journal of medicinal chemistry

Published: August 01, 2024

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma.

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma.

Journal: European journal of cancer (Oxford, England : 1990)

Published: July 23, 2024

Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections.

Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections.

Journal: Drug discovery today

Published: May 31, 2024

The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors.

The synthesis of 1,2,3-triazoles as binders of D-dopachrome tautomerase (D-DT) for the development of dual-targeting inhibitors.

Journal: European journal of medicinal chemistry

Published: May 23, 2024

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms.

Small Molecule MIF Modulation Enhances Ferroptosis by Impairing DNA Repair Mechanisms.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: May 14, 2024

Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages.

Histone Deacetylase 3-Directed PROTACs Have Anti-inflammatory Potential by Blocking Polarization of M0-like into M1-like Macrophages.

Journal: Angewandte Chemie (International ed. in English)

Published: July 20, 2023

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos.

Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos.

Journal: Journal of medicinal chemistry

Published: June 23, 2023

Protocol of the Double-Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins.

Protocol of the Double-Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins.

Journal: Current protocols

Published: June 20, 2023

Showing 1-12 of 95

Last Updated: 09/26/2026