Franziska Koser

Muenster, NW, Germany

Last Updated: 09/26/2026

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Found 15 publications

Biallelic titin truncation disrupts sarcomere assembly and function in patient-derived iPSC-cardiomyocytes.

Biallelic titin truncation disrupts sarcomere assembly and function in patient-derived iPSC-cardiomyocytes.

Journal: Journal of molecular and cellular cardiology

Published: March 13, 2026

Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis.

Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis.

Journal: Nature cardiovascular research

Published: October 01, 2025

Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy.

Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy.

Journal: Science (New York, N.Y.)

Published: September 11, 2025

Direction-dependent contributions of cardiac myofilament networks to myocardial passive stiffness reveal a major disparity for titin.

Direction-dependent contributions of cardiac myofilament networks to myocardial passive stiffness reveal a major disparity for titin.

Journal: Basic research in cardiology

Published: October 21, 2024

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.

Journal: European heart journal

Published: August 19, 2024

Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix.

Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix.

Journal: Nature cardiovascular research

Published: May 07, 2023

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency.

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency.

Journal: bioRxiv : the preprint server for biology

Published: February 07, 2023

Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function.

Genetic ablation of Lmp2 increases the susceptibility for impaired cardiac function.

Journal: Frontiers in molecular biosciences

Published: January 20, 2023

Acetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment.

Acetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment.

Journal: Life sciences

Published: July 16, 2022

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.

Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations.

Journal: Science translational medicine

Published: November 03, 2021

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle.

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle.

Journal: eLife

Published: October 17, 2020

Nicotinamide for the treatment of heart failure with preserved ejection fraction.

Nicotinamide for the treatment of heart failure with preserved ejection fraction.

Journal: Science translational medicine

Published: July 18, 2020

Showing 1-12 of 15

Last Updated: 09/26/2026