Frederic Checler

Ipmc Umr 7275 Cnrs Uns
Valbonne, 06560, France

Last Updated: 09/26/2026

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Found 105 publications

PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains.

PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains.

Journal: Autophagy

Published: May 05, 2026

Functional relationships linking C99/APP-βCTF dimerization, proteostasis disruption, and organelle dysfunction.

Functional relationships linking C99/APP-βCTF dimerization, proteostasis disruption, and organelle dysfunction.

Journal: Cell communication and signaling : CCS

Published: November 14, 2025

Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

Editorial Expression of Concern: Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

Journal: Nature medicine

Published: July 27, 2025

Hampered AMPK-ULK1 cascade in Alzheimer's disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin.

Hampered AMPK-ULK1 cascade in Alzheimer's disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin.

Journal: Alzheimer's research & therapy

Published: March 06, 2025

Suppression of MT5-MMP Reveals Early Modulation of Alzheimer's Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice.

Suppression of MT5-MMP Reveals Early Modulation of Alzheimer's Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice.

Journal: Biomolecules

Published: October 30, 2024

TFinder: A Python Web Tool for Predicting Transcription Factor Binding Sites.

TFinder: A Python Web Tool for Predicting Transcription Factor Binding Sites.

Journal: Journal of molecular biology

Published: August 08, 2024

α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance.

α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance.

Journal: Cell death & disease

Published: July 29, 2024

Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks.

Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks.

Journal: Acta neuropathologica communications

Published: May 23, 2024

Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.

Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.

Journal: Journal of extracellular vesicles

Published: February 05, 2024

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.

Journal: The Journal of biological chemistry

Published: December 03, 2023

Potentially Pathogenic SORL1 Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing.

Potentially Pathogenic SORL1 Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing.

Journal: Cells

Published: September 29, 2023

The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.

The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease.

Journal: Cell death & disease

Published: August 04, 2023

Showing 1-12 of 105

Last Updated: 09/26/2026