Frederic Cumin

Basel, BS 4056, Switzerland

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 17 publications

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.

Journal: Journal of medicinal chemistry

Published: February 20, 2020

Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.

Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.

Journal: ACS medicinal chemistry letters

Published: December 05, 2019

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.

Journal: Journal of medicinal chemistry

Published: April 18, 2019

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: March 31, 2019

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.

Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D.

Journal: ACS medicinal chemistry letters

Published: March 03, 2018

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.

Journal: Journal of medicinal chemistry

Published: June 17, 2017

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.

Journal: Journal of medicinal chemistry

Published: February 04, 2017

The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.

The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.

Journal: Toxicology and applied pharmacology

Published: October 21, 2016

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Small-molecule factor D inhibitors targeting the alternative complement pathway.

Journal: Nature chemical biology

Published: May 20, 2016

Structure of neprilysin in complex with the active metabolite of sacubitril.

Structure of neprilysin in complex with the active metabolite of sacubitril.

Journal: Scientific reports

Published: February 22, 2016

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.

Journal: Bioorganic & medicinal chemistry letters

Published: January 14, 2015

trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.

trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.

Journal: Bioorganic & medicinal chemistry letters

Published: January 14, 2015

Showing 1-12 of 17

Last Updated: 09/26/2026