Frederik B. Pruijn

85 Park Rd
Grafton, AUK 1023, New Zealand

Last Updated: 09/26/2026

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Found 17 publications

Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models.

Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models.

Journal: Molecular oncology

Published: October 02, 2023

Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.

Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System.

Journal: Frontiers in pharmacology

Published: April 28, 2021

Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.

Spatially-resolved pharmacokinetic/pharmacodynamic modelling of bystander effects of a nitrochloromethylbenzindoline hypoxia-activated prodrug.

Journal: Cancer chemotherapy and pharmacology

Published: April 15, 2021

Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures.

Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures.

Journal: Frontiers in pharmacology

Published: June 01, 2018

Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects.

Cellular pharmacology of evofosfamide (TH-302): A critical re-evaluation of its bystander effects.

Journal: Biochemical pharmacology

Published: May 29, 2018

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides.

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides.

Journal: Journal of medicinal chemistry

Published: December 19, 2017

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Journal: Frontiers in pharmacology

Published: June 26, 2017

Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy.

Influence of a Basic Side Chain on the Properties of Hypoxia-Selective Nitro Analogues of the Duocarmycins: Demonstration of Substantial Anticancer Activity in Combination with Irradiation or Chemotherapy.

Journal: Journal of medicinal chemistry

Published: June 24, 2017

Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210.

Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210.

Journal: Pharmacology

Published: August 14, 2015

Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs.

Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs.

Journal: Anesthesia and analgesia

Published: March 31, 2015

Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.

Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.

Journal: Chembiochem : a European journal of chemical biology

Published: May 21, 2014

Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA.

Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA.

Journal: ChemMedChem

Published: May 01, 2014

Showing 1-12 of 17

Last Updated: 09/26/2026