Frederik R. Rombouts

Janssen R&D
Beerse, VLG, Belgium

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 37 publications

In Pursuit of Best-in-Class MCL-1 Inhibitors: Discovery of Highly Potent 1,4-Indoyl Macrocycles with Favorable Physicochemical Properties.

In Pursuit of Best-in-Class MCL-1 Inhibitors: Discovery of Highly Potent 1,4-Indoyl Macrocycles with Favorable Physicochemical Properties.

Journal: Journal of medicinal chemistry

Published: August 18, 2025

Therapeutic indications for HDAC6 inhibitors in the peripheral and central nervous disorders.

Therapeutic indications for HDAC6 inhibitors in the peripheral and central nervous disorders.

Journal: Expert opinion on therapeutic targets

Published: September 21, 2024

Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.

Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.

Journal: Journal of medicinal chemistry

Published: April 28, 2023

Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1.

Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1.

Journal: ACS medicinal chemistry letters

Published: April 16, 2023

Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.

Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.

Journal: Journal of medicinal chemistry

Published: September 23, 2021

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

Journal: Journal of medicinal chemistry

Published: September 23, 2021

Expedient Access to Cyanated N-Heterocycles by Direct Flow-Electrochemical C(sp2 )-H Activation.

Expedient Access to Cyanated N-Heterocycles by Direct Flow-Electrochemical C(sp2 )-H Activation.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: September 15, 2021

Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

Journal: European journal of medicinal chemistry

Published: September 03, 2021

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

Journal: ACS medicinal chemistry letters

Published: August 18, 2021

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

Journal: Journal of medicinal chemistry

Published: March 15, 2021

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats.

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats.

Journal: Drug delivery

Published: November 10, 2020

Small-molecule BACE1 inhibitors: a patent literature review (2011 to 2020).

Small-molecule BACE1 inhibitors: a patent literature review (2011 to 2020).

Journal: Expert opinion on therapeutic patents

Published: October 02, 2020

Showing 1-12 of 37

Last Updated: 09/26/2026