Gabriele Cruciani

Via Dell'Elce Di Sotto 8
Perugia, 06123, Italy

Last Updated: 09/26/2026

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Found 122 publications

A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors.

A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors.

Journal: Journal of medicinal chemistry

Published: April 29, 2026

Discovery of a tetrahydrobenzothiophen-2-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide-based PROTAC as degrader of SARS-CoV-2 main protease.

Discovery of a tetrahydrobenzothiophen-2-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide-based PROTAC as degrader of SARS-CoV-2 main protease.

Journal: European journal of medicinal chemistry

Published: December 30, 2025

Advancing spatial-omics through Pyxis, vendor-neutral software for ion mobility mass spectrometry imaging data analysis.

Advancing spatial-omics through Pyxis, vendor-neutral software for ion mobility mass spectrometry imaging data analysis.

Journal: Analytical and bioanalytical chemistry

Published: September 28, 2025

Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.

Towards sustainable lipidomics: computational screening and experimental validation of chloroform-free alternatives for lipid extraction.

Journal: Analytical and bioanalytical chemistry

Published: May 25, 2025

Target Mapping in Cancer: Ligandable Protein Pockets on 3D OncoPPI Networks.

Target Mapping in Cancer: Ligandable Protein Pockets on 3D OncoPPI Networks.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: May 15, 2025

Selection of short Gadd45β-binding peptides through a synergistic computational and biophysical approach.

Selection of short Gadd45β-binding peptides through a synergistic computational and biophysical approach.

Journal: Protein science : a publication of the Protein Society

Published: May 14, 2025

Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.

Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.

Journal: European journal of medicinal chemistry

Published: March 03, 2025

Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease Mpro dimer.

Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease Mpro dimer.

Journal: International journal of biological macromolecules

Published: February 27, 2025

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs.

Between Theory and Practice: Computational/Experimental Integrated Approaches to Understand the Solubility and Lipophilicity of PROTACs.

Journal: Journal of medicinal chemistry

Published: September 13, 2024

Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis.

Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis.

Journal: Organic & biomolecular chemistry

Published: April 11, 2024

Discovery and Structure-Activity Relationships of Novel ssDAF-12 Receptor Modulators.

Discovery and Structure-Activity Relationships of Novel ssDAF-12 Receptor Modulators.

Journal: Journal of medicinal chemistry

Published: February 28, 2024

Identification of small molecules affecting the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore.

Identification of small molecules affecting the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore.

Journal: Scientific reports

Published: December 16, 2023

Showing 1-12 of 122

Last Updated: 09/26/2026