Gabriella D'orazi

Rome, 00144, Italy

Last Updated: 09/26/2026

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Found 85 publications

Correction: Di Crosta et al. Valemetostat-SAHA-Driven Acetylation of p53 via SET/TAF-Iβ Displacement and p300 Activation Modulates Cell Cycle Regulators in Pancreatic Cancer Cells. Biomedicines 2025, 13, 2279.

Correction: Di Crosta et al. Valemetostat-SAHA-Driven Acetylation of p53 via SET/TAF-Iβ Displacement and p300 Activation Modulates Cell Cycle Regulators in Pancreatic Cancer Cells. Biomedicines 2025, 13, 2279.

Journal: Biomedicines
Published: April 15, 2026

The yin and yang interplay between HDAC6 and KDM1 regulates the lysosomal degradation of mutp53 in colon cancer cells undergoing TG-induced ER stress.

The yin and yang interplay between HDAC6 and KDM1 regulates the lysosomal degradation of mutp53 in colon cancer cells undergoing TG-induced ER stress.

Journal: Biochimica et biophysica acta. Molecular cell research
Published: January 28, 2026

Acetylation promotes mutant (MUT) TP53-HSPA8 and HSPA8-BAG3 interactions, facilitating MUT TP53 lysosomal degradation preferentially via CASA.

Acetylation promotes mutant (MUT) TP53-HSPA8 and HSPA8-BAG3 interactions, facilitating MUT TP53 lysosomal degradation preferentially via CASA.

Journal: Autophagy
Published: October 16, 2025

Valemetostat-SAHA-Driven Acetylation of p53 via SET/TAF-Iβ Displacement and p300 Activation Modulates Cell Cycle Regulators in Pancreatic Cancer Cells.

Valemetostat-SAHA-Driven Acetylation of p53 via SET/TAF-Iβ Displacement and p300 Activation Modulates Cell Cycle Regulators in Pancreatic Cancer Cells.

Journal: Biomedicines
Published: July 23, 2025

Ionizing Radiation in Clinical Diagnostics and Radiotherapy: The Dual Role of NRF2 in Cell Protection and Carcinogenesis.

Ionizing Radiation in Clinical Diagnostics and Radiotherapy: The Dual Role of NRF2 in Cell Protection and Carcinogenesis.

Journal: Frontiers in bioscience (Landmark edition)
Published: April 17, 2025

Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma.

Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma.

Journal: Discover oncology
Published: December 24, 2024

Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.

Mutant p53 upregulates HDAC6 to resist ER stress and facilitates Ku70 deacetylation, which prevents its degradation and mitigates DNA damage in colon cancer cells.

Journal: Cell death discovery
Published: November 13, 2024

Pyrazolone-Based Zn(II) Complexes Display Antitumor Effects in Mutant p53-Carrying Cancer Cells.

Pyrazolone-Based Zn(II) Complexes Display Antitumor Effects in Mutant p53-Carrying Cancer Cells.

Journal: Journal of medicinal chemistry
Published: September 02, 2024

HIPK2 in Colon Cancer: A Potential Biomarker for Tumor Progression and Response to Therapies.

HIPK2 in Colon Cancer: A Potential Biomarker for Tumor Progression and Response to Therapies.

Journal: International journal of molecular sciences
Published: June 24, 2024

Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53.

Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53.

Journal: Biology
Published: June 13, 2024

SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.

SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells.

Journal: International journal of molecular sciences
Published: May 27, 2024

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions.

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions.

Journal: Biomolecules
Published: May 07, 2024
Showing 1-12 of 85

Last Updated: 09/26/2026