Gao-shang Chai
Wuxi, 214122, China
Last Updated: 09/26/2026
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Found 34 publications
Immune cell-specific genetic architecture of Alzheimer's disease revealed by multi-omics analysis for therapeutic target discovery and prioritization.
Journal: Translational psychiatry
Published: January 02, 2026
Aerobic exercise facilitates p300 nuclear translocation via ADRB2-AMPKα signaling, leading to enhanced histone acetylation and mitigation of cognitive decline in APP/PS1 mice.
Journal: Alzheimer's research & therapy
Published: December 02, 2025
ATOX1 deficiency induces memory impairment via promoting cuproptosis in Alzheimer's disease.
Journal: Journal of advanced research
Published: November 24, 2025
Aβ and tau clearance through aerobic exercise: unveiling the β2-adrenergic receptor's role in regulating autophagy-lysosomal pathways.
Journal: Autophagy reports
Published: November 03, 2025
Hdac11 promotes idiopathic pulmonary fibrosis through macrophage M2-type polarization and myofibroblast accumulation by inhibiting Parkin-dependent mitophagy.
Journal: Nature communications
Published: July 03, 2025
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease.
Journal: Experimental & molecular medicine
Published: April 15, 2025
Aerobic Exercise Attenuates Autophagy-Lysosomal Flux Deficits via β2-AR-Mediated ESCRT-III Subunit CHMP4B in Mice With Human MAPT P301L.
Journal: Aging cell
Published: March 13, 2025
Capsaicin Alleviates Autophagy-Lysosomal Dysfunction via PPARA-Mediated V-ATPase Subunit ATP6V0E1 Signaling in 3xTg-AD Mice.
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: February 12, 2025
Upregulation of ISG15 induced by MAPT/tau accumulation represses autophagic flux by inhibiting HDAC6 activity: a vicious cycle in Alzheimer disease.
Journal: Autophagy
Published: December 05, 2024
Homocysteine interferes with Ndufa1 leading to mitochondrial dysfunction through repression of the NAD+/Sirt1 pathway in the brain: a possible link between hyperhomocysteinemia and neurodegeneration.
Journal: Cell death & disease
Published: November 29, 2024
H3K4 Trimethylation Mediate Hyperhomocysteinemia Induced Neurodegeneration via Suppressing Histone Acetylation by ANP32A.
Journal: Molecular neurobiology
Published: December 05, 2023
Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice.
Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice.
Journal: CNS neuroscience & therapeutics
Published: November 26, 2023
Last Updated: 09/26/2026