Gaoya Xu

State Key Laboratory Of Drug Research
Shanghai, China

Last Updated: 09/26/2026

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Found 15 publications

Identification of Novel β-Lactam Derivatives as Proteasome Inhibitors for Antitumor Therapy.

Identification of Novel β-Lactam Derivatives as Proteasome Inhibitors for Antitumor Therapy.

Journal: Archiv der Pharmazie

Published: March 19, 2025

Palladium-Catalyzed Enantioselective Arylative Dearomatization of Naphthols and Phenols for Constructing Quinazoline-Containing Spirocycles.

Palladium-Catalyzed Enantioselective Arylative Dearomatization of Naphthols and Phenols for Constructing Quinazoline-Containing Spirocycles.

Journal: Angewandte Chemie (International ed. in English)

Published: February 10, 2025

Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides.

Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides.

Journal: Bioorganic chemistry

Published: December 28, 2024

Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation.

Potent and selective LSD1 inhibitor DC551040 reveals a promising combination therapy for AML with insight into epigenetic dysregulation.

Journal: Signal transduction and targeted therapy

Published: December 24, 2024

Integrative proteogenomic and pharmacological landscape of acute myeloid leukaemia.

Integrative proteogenomic and pharmacological landscape of acute myeloid leukaemia.

Journal: Science bulletin

Published: June 24, 2024

Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1.

Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1.

Journal: RSC medicinal chemistry

Published: October 25, 2023

Design, Synthesis, and Biological Evaluation of 2-Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors.

Design, Synthesis, and Biological Evaluation of 2-Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors.

Journal: ChemMedChem

Published: December 05, 2022

Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia.

Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia.

Journal: Nature communications

Published: May 09, 2022

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

Journal: Journal of medicinal chemistry

Published: February 24, 2022

Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia.

Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia.

Journal: ChemMedChem

Published: November 11, 2020

Corrigendum to "MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways" [Cancer Letters 337 (2013) 226-236].

Corrigendum to "MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways" [Cancer Letters 337 (2013) 226-236].

Journal: Cancer letters

Published: January 27, 2020

Corrigendum to "MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways" [Canc. Lett. 337 (2013) 226-236].

Corrigendum to "MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways" [Canc. Lett. 337 (2013) 226-236].

Journal: Cancer letters

Published: January 14, 2020

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Last Updated: 09/26/2026