Gareth T. Young

Gunnels Wood Road
Stevenage, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

GWAS of extended prescription analgesic use identifies genetic loci in chronic pain.

GWAS of extended prescription analgesic use identifies genetic loci in chronic pain.

Journal: Nature communications

Published: February 06, 2025

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo.

In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo.

Journal: mAbs

Published: April 25, 2020

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Nav1.7.

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Nav1.7.

Journal: BMC medical genetics

Published: February 02, 2018

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.

An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.

Journal: Structure (London, England : 1993)

Published: August 08, 2017

Identification of Positive Allosteric Modulators of Glycine Receptors from a High-Throughput Screen Using a Fluorescent Membrane Potential Assay.

Identification of Positive Allosteric Modulators of Glycine Receptors from a High-Throughput Screen Using a Fluorescent Membrane Potential Assay.

Journal: Journal of biomolecular screening

Published: July 15, 2016

A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV).

A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV).

Journal: Human mutation

Published: April 29, 2016

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Journal: Science translational medicine

Published: October 29, 2015

Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception.

Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception.

Journal: Nature genetics

Published: July 30, 2015

Transcriptional regulator PRDM12 is essential for human pain perception.

Transcriptional regulator PRDM12 is essential for human pain perception.

Journal: Nature genetics

Published: September 29, 2014

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: January 12, 2014

Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.

Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels.

Journal: Pain

Published: December 11, 2013

HCN2 ion channels: an emerging role as the pacemakers of pain.

HCN2 ion channels: an emerging role as the pacemakers of pain.

Journal: Trends in pharmacological sciences

Published: February 08, 2012

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Last Updated: 09/26/2026