Geert J. Sterk

Amsterdam, NH, Netherlands

Last Updated: 09/26/2026

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Found 29 publications

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling.

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling.

Journal: mSphere

Published: September 24, 2024

The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity.

The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity.

Journal: ChemMedChem

Published: May 30, 2024

Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

Lead Optimization of the 5-Phenylpyrazolopyrimidinone NPD-2975 toward Compounds with Improved Antitrypanosomal Efficacy.

Journal: Journal of medicinal chemistry

Published: February 08, 2024

Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy.

Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy.

Journal: Journal of medicinal chemistry

Published: July 20, 2023

Structural Optimization of BIPPO Analogs as Potent Antimalarials.

Structural Optimization of BIPPO Analogs as Potent Antimalarials.

Journal: Molecules (Basel, Switzerland)

Published: May 28, 2023

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.

Journal: Journal of medicinal chemistry

Published: March 06, 2023

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

Journal: International journal of molecular sciences

Published: February 07, 2023

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.

Journal: Journal of medicinal chemistry

Published: January 12, 2023

3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity.

3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity.

Journal: International journal for parasitology. Drugs and drug resistance

Published: January 15, 2022

Spatial and Spatiotemporal Variability of Regional Background Ultrafine Particle Concentrations in the Netherlands.

Spatial and Spatiotemporal Variability of Regional Background Ultrafine Particle Concentrations in the Netherlands.

Journal: Environmental science & technology

Published: December 30, 2020

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes.

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes.

Journal: Frontiers in chemistry

Published: September 20, 2020

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening.

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening.

Journal: Frontiers in chemistry

Published: September 18, 2020

Showing 1-12 of 29

Last Updated: 09/26/2026