Geoff V. Thompson

Parkville, VIC 3052, Australia

Last Updated: 09/26/2026

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Found 17 publications

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

Journal: ACS chemical neuroscience
Published: June 30, 2026

Childhood motor speech disorders: who to prioritise for genetic testing.

Childhood motor speech disorders: who to prioritise for genetic testing.

Journal: European journal of human genetics : EJHG
Published: June 15, 2025

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.

Journal: Journal of medicinal chemistry
Published: July 18, 2024

Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.

Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.

Journal: Nature chemical biology
Published: March 06, 2023

Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor.

Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor.

Journal: Molecular pharmacology
Published: December 07, 2022

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Journal: eLife
Published: September 15, 2022

Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.

Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.

Journal: ACS chemical neuroscience
Published: April 05, 2022

Structural basis of efficacy-driven ligand selectivity at GPCRs.

Structural basis of efficacy-driven ligand selectivity at GPCRs.

Journal: Nature chemical biology
Published: March 28, 2022

Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.

Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.

Journal: ACS chemical neuroscience
Published: August 05, 2021

Crystal structure of the M5 muscarinic acetylcholine receptor.

Crystal structure of the M5 muscarinic acetylcholine receptor.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: November 28, 2019

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.

Journal: Nature communications
Published: August 14, 2018

Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial.

Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial.

Journal: Anesthesia and analgesia
Published: March 14, 2018
Showing 1-12 of 17

Last Updated: 09/26/2026