Ghanshyam Swarup

Hyderabad, TG 500007, India

Last Updated: 09/26/2026

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Found 31 publications

Glaucoma-associated polymorphism M98K-OPTN sensitizes retinal cells to protein homeostasis stress through p62-mediated caspase activation.

Glaucoma-associated polymorphism M98K-OPTN sensitizes retinal cells to protein homeostasis stress through p62-mediated caspase activation.

Journal: Biochimica et biophysica acta. Molecular cell research

Published: April 30, 2025

Molecular aspects of cytoprotection by Optineurin during stress and disease.

Molecular aspects of cytoprotection by Optineurin during stress and disease.

Journal: Biochimica et biophysica acta. Molecular cell research

Published: September 16, 2024

A cytoprotective role for optineurin during mycobacterial infection of macrophages.

A cytoprotective role for optineurin during mycobacterial infection of macrophages.

Journal: Biochemistry and biophysics reports

Published: December 26, 2023

Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants.

Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants.

Journal: Progress in molecular biology and translational science

Published: January 11, 2023

Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3.

Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3.

Journal: Biochemical and biophysical research communications

Published: November 18, 2022

A glaucoma-associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α.

A glaucoma-associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α.

Journal: The FEBS journal

Published: August 08, 2022

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice.

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: February 04, 2022

Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3.

Autophagy-independent cytoprotection by optineurin from toxicity of aggregates formed by mutant huntingtin and mutant ataxin-3.

Journal: Journal of biochemistry

Published: June 29, 2021

HSC70 as a sensor of low temperature: role in cold-triggered autoinflammatory disorders.

HSC70 as a sensor of low temperature: role in cold-triggered autoinflammatory disorders.

Journal: The FEBS journal

Published: June 22, 2021

Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.

Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.

Journal: Neurochemistry international

Published: December 11, 2020

Optineurin modulates ER stress-induced signaling pathways and cell death.

Optineurin modulates ER stress-induced signaling pathways and cell death.

Journal: Biochemical and biophysical research communications

Published: November 06, 2020

A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.

A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.

Journal: The FEBS journal

Published: May 21, 2020

Showing 1-12 of 31

Last Updated: 09/26/2026