Ghazaleh Sedighi-Eskandari

Edmonton, AB T6G2H7, Canada

Last Updated: 09/26/2026

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Found 23 publications

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.

Journal: Research square

Published: February 13, 2026

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.

Journal: bioRxiv : the preprint server for biology

Published: February 06, 2026

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.

Journal: Molecular neurodegeneration

Published: January 14, 2026

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.

Journal: Science translational medicine

Published: December 03, 2025

Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction.

Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction.

Journal: Research square

Published: November 24, 2025

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo.

Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Published: July 20, 2025

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies.

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: July 01, 2025

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins.

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins.

Journal: Cell stem cell

Published: July 10, 2024

Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.

Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.

Journal: ACS chemical neuroscience

Published: December 14, 2023

Microglial APOE4: more is less and less is more.

Microglial APOE4: more is less and less is more.

Journal: Molecular neurodegeneration

Published: November 28, 2023

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice.

Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice.

Journal: Molecular neurodegeneration

Published: July 10, 2023

Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.

Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.

Journal: Nature

Published: January 29, 2023

Showing 1-12 of 23

Last Updated: 09/26/2026