Giacomo Landi
Siena, 53100, Italy
Last Updated: 09/26/2026
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Found 14 publications
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach.
Journal: Journal of medicinal chemistry
Published: September 30, 2025
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents.
Journal: ACS infectious diseases
Published: July 02, 2024
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.
Journal: European journal of medicinal chemistry
Published: September 11, 2023
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
Journal: Journal of medicinal chemistry
Published: June 08, 2022
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases.
Journal: Pharmaceuticals (Basel, Switzerland)
Published: October 31, 2021
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase.
Journal: Pharmaceuticals (Basel, Switzerland)
Published: May 31, 2021
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor.
Journal: Acta crystallographica. Section D, Structural biology
Published: November 05, 2019
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors.
Journal: ACS infectious diseases
Published: April 24, 2019
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
Journal: Journal of medicinal chemistry
Published: March 26, 2019
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.
Journal: SLAS discovery : advancing life sciences R & D
Published: February 21, 2019
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.
Journal: Molecules (Basel, Switzerland)
Published: February 07, 2017
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.
Journal: Journal of medicinal chemistry
Published: July 15, 2016
Last Updated: 09/26/2026