Giacomo Paonessa

Rome, 00071, Italy

Last Updated: 09/26/2026

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Found 11 publications

Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo Efficacy.

Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo Efficacy.

Journal: Journal of medicinal chemistry

Published: May 29, 2026

An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models.

An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models.

Journal: Nature communications

Published: May 15, 2025

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.

Journal: Communications biology

Published: February 09, 2022

SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.

SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.

Journal: Bioorganic & medicinal chemistry

Published: July 30, 2021

Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.

Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT.

Journal: Bioorganic & medicinal chemistry letters

Published: February 24, 2020

Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.

Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: January 13, 2020

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Journal: PLoS neglected tropical diseases

Published: December 19, 2019

Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.

Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.

Journal: Bioorganic & medicinal chemistry letters

Published: September 25, 2018

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production.

Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production.

Journal: Parasites & vectors

Published: September 19, 2018

Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.

Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins.

Journal: Bioorganic & medicinal chemistry letters

Published: December 22, 2017

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.

Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.

Journal: ACS medicinal chemistry letters

Published: December 07, 2015

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Last Updated: 09/26/2026