Giambattista Guaitoli

Otfried Müller Str. 23
Tuebingen, BW 72076, Germany

Last Updated: 09/26/2026

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Found 11 publications

Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism.

Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism.

Journal: eLife

Published: December 19, 2024

The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation.

The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation.

Journal: Frontiers in neuroscience

Published: September 26, 2024

Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies.

Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies.

Journal: eLife

Published: April 26, 2024

Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.

Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.

Journal: ACS chemical neuroscience

Published: May 18, 2023

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: January 24, 2022

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding.

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding.

Journal: eLife

Published: February 21, 2019

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Journal: Biological chemistry

Published: April 18, 2018

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

Journal: Nature communications

Published: September 16, 2016

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.

Journal: Biochemical Society transactions

Published: August 04, 2016

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

Journal: Brain : a journal of neurology

Published: July 29, 2016

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: July 01, 2016

Showing 1-11 of 11

Last Updated: 09/26/2026