Gian F. Ruda
Oxford, ENG OX37FZ, United Kingdom
Last Updated: 09/26/2026
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Found 13 publications
The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.
Journal: Brain research bulletin
Published: May 19, 2023
The structural basis of fatty acid elongation by the ELOVL elongases.
Journal: Nature structural & molecular biology
Published: October 22, 2020
Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity.
Journal: Cell reports
Published: June 17, 2019
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Journal: European journal of medicinal chemistry
Published: January 04, 2019
Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.
Journal: Journal of medicinal chemistry
Published: February 10, 2017
Assessing histone demethylase inhibitors in cells: lessons learned.
Journal: Epigenetics & chromatin
Published: December 13, 2016
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Journal: Cell chemical biology
Published: April 02, 2016
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Journal: Journal of medicinal chemistry
Published: January 08, 2016
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Journal: Science (New York, N.Y.)
Published: March 14, 2015
N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.
Journal: ACS chemical biology
Published: February 24, 2015
Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.
Journal: Chemical communications (Cambridge, England)
Published: November 28, 2014
Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase.
Journal: Chemical communications (Cambridge, England)
Published: April 03, 2014
Last Updated: 09/26/2026