Giorgio Ottaviani

Building 5, 371 Lishizhen Road
Shanghai, 201203, China

Last Updated: 09/26/2026

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Found 16 publications

Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus.

Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus.

Journal: Journal of medicinal chemistry

Published: October 06, 2023

Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.

Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.

Journal: Journal of medicinal chemistry

Published: March 10, 2023

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.

Journal: Journal of medicinal chemistry

Published: June 13, 2020

An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.

An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.

Journal: Regulatory toxicology and pharmacology : RTP

Published: December 05, 2017

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

Journal: The EMBO journal

Published: November 22, 2017

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

Journal: The Journal of pharmacology and experimental therapeutics

Published: October 16, 2017

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

Journal: Journal of medicinal chemistry

Published: March 25, 2017

A novel orally available small molecule that inhibits hepatitis B virus expression.

A novel orally available small molecule that inhibits hepatitis B virus expression.

Journal: Journal of hepatology

Published: March 01, 2017

An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study.

An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study.

Journal: Bioanalysis

Published: January 24, 2017

Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.

Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: July 18, 2016

Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic Nephropathy.

Therapy with a Selective Cannabinoid Receptor Type 2 Agonist Limits Albuminuria and Renal Injury in Mice with Type 2 Diabetic Nephropathy.

Journal: Nephron

Published: October 08, 2015

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.

Journal: Journal of medicinal chemistry

Published: September 26, 2015

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Last Updated: 09/26/2026