Giovanni Bottegoni

Urbino, 60129, Italy

Last Updated: 09/26/2026

Save publications for later
Sign Up
Not sure about your diagnosis?
Check Your Symptoms
Found 61 publications

Machine Learning-Based Models to Predict Drug-Induced Liver Injury (DILI) to Assist Medicinal Chemistry.

Machine Learning-Based Models to Predict Drug-Induced Liver Injury (DILI) to Assist Medicinal Chemistry.

Journal: Journal of medicinal chemistry
Published: June 22, 2026

Corrigendum to "Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma" [Bioorg. Chem. 179 (2026) 109997].

Corrigendum to "Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma" [Bioorg. Chem. 179 (2026) 109997].

Journal: Bioorganic chemistry
Published: May 29, 2026

Where do we go from here? Current state of drug-target binding kinetics and a roadmap to their establishment in drug discovery campaigns.

Where do we go from here? Current state of drug-target binding kinetics and a roadmap to their establishment in drug discovery campaigns.

Journal: Drug discovery today
Published: February 25, 2026

Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant.

Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant.

Journal: bioRxiv : the preprint server for biology
Published: February 12, 2026

Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma.

Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma.

Journal: Bioorganic chemistry
Published: January 22, 2026

Bioisosteric Replacement of Carboxylic Acids in PPAR Agonists: A Mini Review.

Bioisosteric Replacement of Carboxylic Acids in PPAR Agonists: A Mini Review.

Journal: Current topics in medicinal chemistry
Published: November 15, 2025

Pyrazolone-based ERO1 inhibitors in ERO1-driven triple-negative breast cancer and SEPN1-related myopathy: Structure-activity relationship and therapeutic potential.

Pyrazolone-based ERO1 inhibitors in ERO1-driven triple-negative breast cancer and SEPN1-related myopathy: Structure-activity relationship and therapeutic potential.

Journal: Pharmacological research
Published: August 26, 2025

Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance.

Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance.

Journal: EBioMedicine
Published: August 26, 2025

Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics.

Adiabatic-Bias Molecular Dynamics Simulations Reveal the Impact of Mutations on Muscarinic Antagonist Unbinding Kinetics.

Journal: Journal of chemical information and modeling
Published: June 16, 2025

Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter-proximal nucleosomes.

Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter-proximal nucleosomes.

Journal: Nucleic acids research
Published: May 28, 2025

Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals.

Application of Deep Learning to Predict the Persistence, Bioaccumulation, and Toxicity of Pharmaceuticals.

Journal: Journal of chemical information and modeling
Published: April 03, 2025

Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.

Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.

Journal: European journal of medicinal chemistry
Published: March 03, 2025
Showing 1-12 of 61

Last Updated: 09/26/2026