Greg R. Markby

Edinburgh, SCT, United Kingdom

Last Updated: 09/26/2026

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Found 13 publications

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.

Journal: Autophagy

Published: February 23, 2025

TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.

TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.

Journal: Frontiers in veterinary science

Published: April 07, 2023

TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.

TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.

Journal: Cell proliferation

Published: December 15, 2022

Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep (Ovis aries).

Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep (Ovis aries).

Journal: Frontiers in genetics

Published: April 24, 2020

Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel.

Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel.

Journal: BMC veterinary research

Published: April 17, 2020

Beyond mineralisation: metabolic functions for matrix mineralisation regulators.

Beyond mineralisation: metabolic functions for matrix mineralisation regulators.

Journal: The Journal of endocrinology

Published: February 11, 2020

Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.

Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.

Journal: Journal of cellular physiology

Published: February 07, 2020

Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling.

Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling.

Journal: Frontiers in genetics

Published: December 17, 2019

Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure.

Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure.

Journal: Veterinary journal (London, England : 1997)

Published: October 31, 2019

Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis.

Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis.

Journal: Research in veterinary science

Published: September 19, 2019

Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration.

Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration.

Journal: PloS one

Published: April 25, 2019

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification.

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification.

Journal: Journal of visualized experiments : JoVE

Published: December 30, 2017

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Last Updated: 09/26/2026