Gregory L. Challis

Gibbet Hill Road
Coventry, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 71 publications

PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases.

PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases.

Journal: JACS Au
Published: December 06, 2025

A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition.

A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition.

Journal: Current biology : CB
Published: October 31, 2025

Trifunctional flavoenzyme-catalyzed asymmetric 4-alkyl-butenolide assembly in avenolide biosynthesis.

Trifunctional flavoenzyme-catalyzed asymmetric 4-alkyl-butenolide assembly in avenolide biosynthesis.

Journal: Nature communications
Published: July 20, 2025

Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks.

Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks.

Journal: Biochemistry
Published: April 11, 2025

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.

Molecular basis for depsipeptide HDAC inhibitor combinatorial biosynthesis.

Journal: Nature communications
Published: March 31, 2025

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis.

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis.

Journal: PLoS biology
Published: February 16, 2025

Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A.

Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A.

Journal: ACS infectious diseases
Published: December 09, 2024

Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements.

Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements.

Journal: mBio
Published: October 18, 2024

Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases.

Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases.

Journal: JACS Au
Published: September 11, 2024

Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.

Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis.

Journal: ACS infectious diseases
Published: August 27, 2024

Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab.

Discovery and Biosynthesis of Streptolateritic Acids A-D: Acyclic Pentacarboxylic Acids from Streptomyces sp. FXJ1.172 with Promising Activity against Potato Common Scab.

Journal: Journal of agricultural and food chemistry
Published: June 20, 2024

Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa.

Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa.

Journal: Journal of the American Society for Mass Spectrometry
Published: June 03, 2024
Showing 1-12 of 71

Last Updated: 09/26/2026